Technical items in Biological fields
1. The production of an organic acid¡ªItaconic acid by fermentation

Itaconic acid is an important chemical material and is a product of high technology,

high profit and high foreign exchanges. It is successfully developed in recent years with abundant resources and is the product to the world market with a high added value. The strain of Itaconic acid was selected and cultured and suitable many kinds of saccharic materials and the acid producing rate, conversion rate and extracting rate were taken on the lead level of the country. The conversion rate of saccharide-acid is over 65%, the acid producing 7.0-8.0%, the fermentation time about 50 hours and extraction reached to 85%. As Itaconic acid is widely utilized in new chemical synthetic material, papermaking, food, medicines, the requirement for it is quickly increased at home and abroad especially supplied falls short of demand in the world market. It shows better economic benefits. The technology has been awarded the first prize of Shandong Technological committee and National Technology Progress Prize in 2000.

As it is a mature technology, it can be supplied complete set of design and processing, the products can be produced on time and quality and quantity guaranteed, moreover, the technology transferred, service and consult can also be supplied.

The total investment of 28¡ª30million yuan for 3000 ton of Itaconic acid annually would be get the annual profit of 10 million yuan

 

2.Xanthan gum¡ªa biological polysaccharides

Xanthan gum a natural high molecular carbohydrate is a widely applied microbiological exocellular acid heteropolysaccharides produced by Xanthomonas with high viscosity, unique rheological property ¨Cpseudoplastic property and high thermal stability. Its viscosity cannot be changed when it is be heated and cooled overtimes in a certain temperature. It can be soluble with most of salts and has acid, alkali and salt tolerant property. It can also be mixed with most of natural and compound thickeners to increase the viscosity. Xanthan gum has manifold applied as thickening agent in food, cosmetic, oil recovery and fire extinguishing.

The technology was awarded a dozen of prizes of which The National Third Prize in 1988, The Important Progress Prize in 1991 and shandong Scientific Tech Progress Prize in 2002.

The strain, production, procedure, engineering, design, products inspection and training can all be supplied, the technologies belong to the knowledge property claim are as follows:

•  The strain which can produce food grade and industrial grade products; special culture medium; fermentation technology; fermentor and stirrer suitable for high viscosity material.

•  Post extract technology with energy saving, machinized, less investment and low cost.

•  The final equipment and technology for producing powder, sand and ball products.

•  A set of improved xanthan gum technology ( including instant, transparent, thermo-resistant xanthan gum extract technology.)

The equipment invest of 25¡ª30 million yuan for 1000 ton/ year and income is 30¡ª40 million yuan / year.

3.The D-ribose production by fermentation

The technology is a new high additional value product developed starch deep processing with biotechnology. With the study on the biological pharmaceuticals for anti-tumor, anti-virus and nucleic acid medicine development, D-ribose as their raw material component is more and more needed on the market. A stable and high yield mutant¡ªBacillus subtilis mutant for D-ribose production was selected. The purity of D-ribose reached to over 99%, which was produced by deep aerobic fermentation and taking glucose as its material with quick fermentation and high sugar productive rate and transforming rate. The technology reached to the world level.

Naturally D-ribose doesn't exist as a monomer, it is a series of high expensive biochemical reagent. As it has been produced by cheap microbiological fermentation, the pharmaceutics material riboflavin and ribazole were solved. Especially as its unique function of virus and tumors resistance and an original material for nucleic acid medicines were paid much attention on the market. At present, he price of D-ribose is 32 USD/pound, the annual requirements at home and abroad are about 5000 tons and increase of 11% per year. The cost of fermented D-ribose estimates 50-80yuan /kg for crystal product and the selling price is 300 yuan/kg. If annual output is 200 tons, the value is 60 million yuan, the profits 40 million yuan. The economic benefit is remarkable and has bright future.

4.A new functional polysaccharide¡ªthermal gel

Thermal gel is a special polysaccharide and was permitted as stabilizer, thickener, and conditioner in food component by FDA in USA . As it was formed by linking ¦Â -1,3-glucoside, it cannot be soluble in water and safe for human being. It was solidified an inconvertible gel when heated, which has a character of resisting frozen and defrost. The thermal gel has a function of edible fibre, it cannot be absorbed by human body and also has an anti-tumor, as its ¦Â -1,3-glucoside link, it is characteristic of thickening, viscosity-increasing and rheological property with other polysaccharides, it is a multi-functional food additives.

At present, only Japan , British and a few countries can produce thermal gel industrially, the selling price is about 350-400 yuan/kg, the factories in our country haven't produced it for the technological reason. It was reported the thermal gel was imported 600 tons only from Japan in 2001 and the import has increased of 30% per year. Faced to great market, British, Japan and other countries have set up selling nets from then. Our institute has completed the research work for thermal gel , welcome interested factories consult with us.

The profit is 5 million yuan per year for annual output of 100 tons of thermal gel, but need fermentation and post- extraction equipments. It is suitable for biological plants,

 

5. L-malic acid production by direct fermentation

L-malic acid is one of tricarboxylic acid cycle in organism and exists widely in apple fruits. It odors remarkable and its acid flavor is soft and fresh. Mixed with citric acid, natural fruit flavor can be imitated. It can be used as acid flavor and conditioner in food and also an additional component in amino acid infusion for curing burning patients to increase amino acid utilization and promote the wound heal in pharmaceutical industry. It can also be used to cure assistantly anaemia and liver function exhaustion if it added in medicine to increase the medical stability and promote the absorption in human body. Its utilization can be in fuel, chemical and building materials.

The selling price of L-malic acid is about 50 thousand yuan/ton, the cost of it is about 20 thousand yuan by direct fermentation. The economic benefit is notable.

6.Oligo maltose production technology

Oligo maltose is a new sugar resource of starch deep processing. It is mainly composed of maltose, maltotriose and maltooctose without dextrine. It is a new sweetener from starch affected by oligosacccharidase with the function of prolonging the energy for human body and strengthening endurance. Besides the health function, it can widely used in many kinds of beverages, wines, high grade candies baby food and nutrients and also be used in food treatment for pancreateotemy patients and kidney failure patients as energy resource. Application fields of starch syrup can be changed by oligomaltose which taste, flavour and nutrition are superior to the starch syrup.

The total investment of 3000 tons of oligomaltose is 3.2-3.5million yuan for 7.2-7.5 million yuan of annual profit and tax.

7.High concentrate corn alcohol fermentation and whole grain utilization

Alcohol has been a lead product in food, chemical and medicine in fermentation industry. Because of short of sweet potato chips which were replaced by corn as material in many factories and adopted the whole grain fermentation, the environment was contaminated with poor economic benefit. The technology adopted high yield flocculating alcohol yeast to ferment supernatant alcohol, the alcoholicity reached up to 17%(v/v), the yeast would also be recovery to raise the quality greatly. The technology was able to heighten the multiple utilization of corn maximally and solve the environment contamination. The alcohol production would be doubled and redoubled, the equipment utilization raised greatly and reduced energy, water and cost. The remarkable benefit of economic, social and environment would be got.

The technology would decrease the alcohol cost of ton about 800 yuan. On count of 10 thousand tons of alcohol annually for example, the benefit would increase 8 million yuan.

8. A series of active fermented drinks

The technology adopted fresh fruits eg. apple, haw, pear, peach etc. vegetables eg. carrot, tomato, cucumber, celery etc. grain eg. barley, rice, bean, peanut, mungbean etc. and milk as materials to component scientifically, inoculate related beneficial strain, fermented and blended to produce a nutritive health drink with unique flavor, containing amino acid, vitamins , organic acids and physiological active matters.

Investment: 300-400 thousand yuan for equipments, 80-200 square meters for workshop, 30-100 kv for power.

Benefits: cost of bottle is 0.6-1.0 yuan, annual profits are 250-600 thousand yuan for the output of 2000-5000 bottle per day.

9.The comprehensive control for apple and pear dregs

The waste molasses from production of apple juice and pear juice was fermented to produce alcohol, vinegar, vinegar drinks, cola, cider and brandy etc., which would make out high addition value product, at the same time, the contaminants were controlled and juice quality was raised.

If dealing with 140 ton of waste liquid per day, need 1 million yuan for equipments, 20 workers, 3.5 thousand yuan for steam and 1 thousand yuann for other auxiliary expense to produce 3.5 tons of alcohol, the income would be 11.2 thousand yuan. If the factory worked eight months one year, the annual income would be 1.5 million yuan. It did not only remedy the expense of control contamination of waste water, but also got better social and economic benefits.

 

10. Starch sugar series production technology

(1). Maltodextrin

(2). Whole sugar ( syrup, powder)

(3). Fructose syrup

(4). Crystalline glucose A Inject glucose B. Oral glucose C. Industrial glucose

(5). Malt syrup

11. Production of organic acid¡ªcitric acid and lactic acid by fermentation

12.Corn wine production technology

13.The spirit and protein feed production by corn dregs

14.The vinegar and protein feed production by starch dregs

15.Apple and vegetables deep processing

16.The lotus wine production

17.The xylanase industrial production

18.Enzymatic producing oligo-xylose

19.The study and development on a new pharmaceutical enzyme¡ªnatto kinase

20.Functional active polypeptides of corn

21.Study on flavor sauce made by corn protein

22.Edible yeast production by crystalline mother liquor of glucose

23.Yeast gourmet powder

24.Food fibre production by corn peel

25.Study on polyase feed by corn peel

26.Brewing strains

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Technical items in food fields

•  Garlic processing

•  Ginger and scallion processing

•  Date processing series

•  Date cola, date juice, date tea, date candied fruit

•  Concentrated juice, instant powder

•  Casein, immune globulin, lactabumin and lactoferrin item

•  Haw series processing

Haw candied fruit, haw concentrate, haw juice powder, haw fresh powder

•  Nutritive vegetable noodle

•  Asparagus dregs utilization

•  Carbon dioxide supercritical extraction of varies of plant essences and pigments

•  Peanut processing

Peanut candies, peanut protein powder, peanut and soybean milk and yoghurt production

•  Dehydrated vegetables technologies

•  Mung bean beverage production

•  Fruit vinegar series preparation

•  Lotus root deep processing

•  Soft dried meat processing

•  Bean products technology

•  Walnut milk production

•  Fruit and vegetables processing

A Fruit and vegetable juice processing

B Natural fruit and fresh drink

18. Mung bean taste production

19. Milk products

A. Pasteurized milk and yoghurt production

B. Fruit milk and active milk technology

20. Cold drink series

21. Shrimp protein chitin production by enzymatic method

22. Solid soda water

23. Collagen polypeptide production

24. Vacuum freeze drying products

25. Animal blood processing

26. Health date wine